A partial view of the original James Pharmacy facade, left. (H Lee Waters, 1937 - NC State Archives)
From the National Register nomination:
This two-story, parapet-roofed, brick commercial building features a yellow-brick façade with metal coping on the parapet. The building has a recessed storefront with paired one-light wood doors under a shared transom. The doors are flanked by plate-glass metal windows on a low knee wall. The storefront has a tile floor, fluted pilasters flanking the storefront, a 1940s-era Moderne carrera glass sign with the "James Pharmacy" name, and a retractable fabric awning. A one-light wood door on the left (south) end of the façade is recessed slightly, accessed by tiled steps, and has a one-light transom and a fabric awning. There are one-over-one aluminum-clad wood-sash windows at the second-floor level. The building appears on the 1924 Sanborn map as a drug store and the interior retains elegant original drug store appointments.
The original facade appears to have been completely removed c. 1940 and replaced with the Moderne facade described above; it appears that the facade replacement was done by the James Pharmacy, which occupied the building prior to the renovation. The original facade had a stepped cornice with a triangular peak, and 2 over 2 windows consistent with a build date in the 1910s.
A poor quality photo looking northwest at North Churton ~1920s. You can make out the triangular peak on the left of the paired two-story buildings at center. (History of the Town of Hillsborough)\
James Pharmacy later became James Drugs
March 1983 (NCSHPO via Tom Campanella/builtbrooklyn.org)
08.31.2016 - with the Moderne façade (G. Kueber)
The first floor has been home to LaPlace restaurant since 2014, which as a native New Orleanian, I greatly appreciate. Immediately prior to LaPlace, a restaurant named "Gulf Rim" was located here. In 2019, much to my disappointment, the owners closed LaPlace and replaced it with a seafood focused restaurant called "James Pharmacy"